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KMID : 0861020000150010101
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Korea Journal of Herbology
2000 Volume.15 No. 1 p.101 ~ p.115
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Study on Antitumor Activity and Immunomodulatory Effect of Bujunghaedoktang
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朴相采/Park, Sang-Chae
宋昊哲/金東熙/徐榮培/朴陽春/金聖勳/Song, Ho-Chul/Kim, Dong-Hee/Seo, oun-Bae/Park, Yang-Chun/Kim, Sung-Hoon
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Abstract
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To evaluate the antitumm activity and immune rsponse of Bujunghoedo!aaCtnng(BJHDn, studies were done experimentally. The rsulLF were OMaineed as fallow:
1. BJHDT e m c b erhibitcd a wmk eytotoxieity against SKOV-3, and SK-MELJ cell lines, while it showed a good effectivaes against BlE-FIO up to 80% of control at concenmion of over 0.25mg/ml
2. BJHDT emcG signifimtly showed an inhibitor, effect on DNA topowmewz I from calf thpw at 500 mglmf.
3. BJHDT eXhaetS showed antiadhesive rates against A549, 30% at 0.5 dm!, 80% at 1 mplm!.
4. BJHDT exmcb inhibited CAM angiogenesis up to 40%.
6. BIHDT extracb prolonged life span of ICR mice bearing S-180 sarcoma cells up to 127.1%.
7. In FACS analysis, the population of helper T cell and tended to increase.
8. Pmliferatbn rate of splenoeyte WBS inneased at 0.5mglml or more in a dase dependent fashim as compared with Control.
These resulb suggested that BIHDT exham might k usefully applied for treatment of cancer and also it was necessary m do more studies about its mechanisms.
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KEYWORD
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